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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often described as focusing on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Pragmatic, a software company offers a range of casino games on online gambling platforms. Its iGaming software is used by the top operators as well as casinos that are located in the land. The company provides front-end site design tools, analysis tools and promotions, marketing security payment systems, customer service and bug-reporting. The company also provides security, high-quality graphics, gameplay and security.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from various geographical areas. This type of heterogeneity, which is vital for a pragmatic trial to be reliable and lessen the chance of bias is also essential. However too much heterogeneity could result in issues with the design of the trial.
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Legality
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically requested by practitioners and policymakers to help guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should not, however be used to replace explanatory studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic trial, including the recruitment process, the design and delivery of the intervention, and the follow-up.
There is a positive trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind that the majority were conducted in primary care settings.