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Pragmatic trials are studies designed to inform real-world clinical practice. They are typically focused on the practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and reduce bias in results is also essential. However too much heterogeneity could cause issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They also provide a useful way to identify the causality between an intervention and its outcomes. They should not, however, be used to replace explanatory studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and 프라그마틱 슬롯 무료프라그마틱 슬롯 조작 프라그마틱 무료 슬롯 (Http://Jade-Crack.com/) pragmatic trials that inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study which includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.