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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of design, including the recruitment and consent process, as well as adherence and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.
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The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can be used to determine the cause-effect relationship of an intervention and its results. They should, however, not, be used to replace explanatory studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis and pragmatic trials that inform the policy and practice of. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a practical trial which includes the recruitment process, the design and delivery of the intervention, and follow-up.
There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note, however, that the majority were conducted in primary-care settings.